2019 ASBMB FELLOWSHIP: NGEE KIAT (JAKE) CHUA
School of Biotechnology and Biomolecular Sciences
Ngee Kiat (Jake) Chua completed his Bachelor of Science (Honours) at UNSW Sydney with support from the UNSW Golden Jubilee Scholarship. In 2015, he undertook his Honours year under the supervision of Professor Andrew Brown, graduating with a First Class Honours and the University Medal in Molecular and Cell Biology. His Honours work contributed to a publication in the Journal of Biological Chemistry.
In 2016, he pursued a PhD in the same lab after being granted the University International Postgraduate Award from UNSW Sydney. In his PhD, he investigates the regulation of squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis. He revealed an unconventional cholesterol sensing mechanism and an atypical protein modification in squalene monooxygenase, leading it down the path of destruction. The findings integrate and enrich the knowledge in the fields of membrane biology, lipid sensing and protein degradation.
Now entering his fourth year, he has published as the first author in the Journal of Biological Chemistry and Science Translational Medicine. His first Journal of Biological Chemistry paper in his PhD was selected as Editors’ Pick, representing the top 2% of papers published in the journal. This work was featured in the journal in a special virtual issue ‘Focus on Australasia’ as one of the recent exciting advances from Australia and New Zealand, honoring the 2018 Lorne Conference on Protein Structure and Function. He has also presented in numerous local and international conferences, receiving poster and oral presentation prizes.