Si Ming Man


Department of Immunology and Infectious Disease

Australian National University

Si Ming completed a Bachelor of Medical Science (Hons I, University Medal) at UNSW Sydney. During his Honours year, Si Ming investigated the role of mucus-associated bacteria in children with inflammatory bowel diseases. His interests in host–pathogen interaction inspired his move to the UK, where he completed his PhD at the University of Cambridge in 2013 under the supervision of Professor Clare Bryant. During his PhD, he studied macrophage responses to the foodborne pathogen Salmonella spp. and generated two first-author publications in Proceedings of the National Academy of Sciences USA and a first-author publication in the Journal of Immunology. With the support of an NHMRC RG Menzies Early Career Fellowship, Si Ming moved to Memphis, Tennessee, USA, where he completed his postdoctoral training at St Jude Children’s Research Hospital under the mentorship of Dr Thirumala-Devi Kanneganti. During this time, Si Ming and his colleagues identified (1) a role for disease-fighting proteins in liberating microbial ligands to drive activation of innate immunity (Cell, 2016; Nature Immunology, 2015); (2) the activation mechanisms of immune receptors in cancer (Cell, 2015; Nature, 2016). Si Ming returned to Australia to establish his lab at the Australian National University in 2017. He is now a Professor and NHMRC RD Wright Biomedical Fellow. His laboratory focuses on understanding the role of innate immunity in the host defense against infectious diseases and the development of cancer (Nature Microbiology 2019, Nature Communications, 2020).

Si Ming was a recipient of the Pfizer-Showell Award (2019) and the Thermo Fisher Trainee Achievement Award (2016) from the American Association of Immunologists, the Milstein Young Investigator Award from the International Cytokine and Interferon Society (2016), the Jim Pittard Early Career Award from the Australian Society for Microbiology (2017), the Royal Society of NSW Edgeworth David Medal (2019), an NHMRC Research Excellence Award for the highest-ranked Early Career Fellowship (2015) and an NHMRC Research Excellence Award for the highest-ranked Career Development Fellowship Biomedical Level 1 (2019). He also received the 2019 Commonwealth Health Minister’s Medal for Excellence in Health and Medical Research.