Yanxiang Meng

2022 ASBMB FELLOWSHIP AND THE FRED COLLINS AWARD: YANXIANG MENG

Walter and Eliza Hall Institute of Medical Research

Yanxiang Meng completed a Bachelor of Science in Biochemistry in 2017 at the University of Canterbury, New Zealand. He continued his studies in Christchurch at the University of Canterbury, completing his Honours in 2018 under Professor Renwick Dobson and Professor Mark Hampton (University of Otago, Christchurch). During this time, Meng investigated the structure and function of alkylhydroperoxidase D from Streptococcus pneumoniae, discovering an unexpected active site architecture, and published these results in Journal of Biological Chemistry. In late 2019, Meng joined the laboratory of Professor James Murphy at the Walter and Eliza Hall Institute of Medical Research. Co-supervised by Associate Professor Peter Czabotar and Dr Jarrod Sandow for PhD studies, Meng’s current research investigates the structural basis of RIPK3-mediated necroptosis signalling and cell death in human cells. During this time, he discovered that human MLKL is maintained by RIPK3 in an inactive conformation prior to necroptosis activation; he also uncovered the structural basis of the conformational switching mechanism of MLKL pseudokinase domain. His research made significant impact in the field of necroptosis, reflected in two first-author papers in Nature Communications and one in Cell Death & Differentiation. Meng’s achievements have been recognised through his receipt of several awards and scholarships, including AINSE Postgraduate Research Award (2020), Melbourne Research Scholarship (2019) and AINSE Honours Scholarship (2018).

Meng is scheduled to present his recent findings at the 88th Harden Conference of the Biochemical Society (Beyond Catalysis – Kinases and Pseudokinases) to be held in Warwickshire, UK.